Spam Assault! 4.0 Professional Edition works to get you removed from the bulk mailing lists.

It accomplishes this by sending "Undeliverable Mail" messages to the sender.

While you're waiting to get removed, SAP lets you manage junk mail by supporting an unlimited number of blocked senders and domains (including wildcard matching).

SAP also identifies fake reply-to addresses and marks offending messages for deletion.

Alternatively, add valid email addresses to the Save List to ensure valid email is never inadvertently deleted.